- Title
- Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
- Creator
- Jaworek, Thomas; Xu, Huichun; Attia, John; Woo, D; Worrall, BB; Hong, CC; Ross, OA; Zand, R; de Leeuw, F-E; Lindgren, AG; Pare, G; Anderson, CD; Markus, HS; Bell, Steven; Jern, C; Malik, R; Dichgans, M; Mitchell, BD; Kittner, SJ; Benavente, Oscar R.; Boncoraglio, Giorgio B.; Butterworth, Adam; Carcel-Marquez, Jara; Chen, Zhengming; Chong, Michael; Cruchaga, Carlos; Cushman, Mary; Gaynor, Brady J.; Danesh, John; Debette, S; Duggan, DJ; Durda, JP; Engstrom, G; Enzinger, C; Faul, JD; Fecteau, NS; Fernandez-Cadenas, I; Gieger, C; Cole, John W.; Giese, A-K; Grewal, RP; Grittner, U; Havulinna, AS; Heitsch, L; Hochberg, MC; Holliday, Elizabeth; Hu, J; Ilinca, A; Irvin, MR; Rannikmae, Kristiina; Jackson, RD; Jacob, MA; Rabionet, R; Jimenez-Conde, J; Johnson, JA; Kamatani, Y; Kardia, SLR; Koido, M; Kubo, M; Lange, L; Stanne, Tara M.; Lee, J-M; Lemmens, R; Levi, CR; Li, J; Li, L; Lin, K; Lopez, H; Luke, S; Maguire, J; McArdle, PF; Tomppo, Liisa; McDonough, CW; Meschia, JF; Metso, T; Mueller-Nurasyid, M; O'Connor, TD; O'Donnell, M; Peddareddygari, LR; Pera, J; Perry, JA; Peters, A; Abedi, Vida; Putaala, J; Ray, D; Rexrode, K; Ribases, M; Rosand, J; Rothwell, PM; Rundek, T; Ryan, KA; Sacco, RL; Salomaa, V; Amouyel, Philippe; Sanchez-Mora, C; Schmidt, R; Sharma, P; Slowik, A; Smith, JA; Smith, NL; Wassertheil-Smoller, S; Soderholm, M; Stine, OC; Strbian, D; Armstrong, Nicole D.; Sudlow, CLM; Tatlisumak, T; Terao, C; Thijs, V; Torres-Aguila, NP; Tregouet, D-A; Tuladhar, AM; Veldink, JH; Walters, RG; Weir, DR
- Relation
- Neurology Vol. 99, Issue 16, p. E1738-E1754
- Publisher Link
- http://dx.doi.org/10.1212/WNL.0000000000201006
- Publisher
- Wolters Kluwer Health
- Resource Type
- journal article
- Date
- 2022
- Description
- Substantial advances have been made in recent years toward identifying common genetic variation associated with risk of ischemic stroke.1,2 This progress has been largely based on meta-analyses of genome-wide association study (GWAS) results derived from predominantly late-onset cases. Given that a higher heritability of early-onset ischemic stroke is observed in multiple studies,3-6 there is a strong need for genetic studies focusing on early-onset stroke (EOS). A pressing question is whether the genetic contribution to EOS includes novel or specific mechanisms that may have translational importance across the whole age spectrum, as has been found from studies of early-onset cases in other complex diseases.7-9 Because atherosclerosis is a less common cause of stroke in young adults, we hypothesized that nonatherosclerotic, prothrombotic mechanisms may be more important and discernible in studies of EOS.10,11 This concept is supported by associations reported between EOS and multiple prothrombotic candidate genes.10-14 In this report, we present findings from the Genetics of Early Onset Ischemic Stroke Consortium, contrast the effect sizes of known stroke loci in early-onset vs late-onset stroke (LOS), and evaluate differing contributions of prothrombotic loci to EOS and LOS.
- Subject
- ischemic stroke; genetic risk score; onset age; controlled study
- Identifier
- http://hdl.handle.net/1959.13/1486937
- Identifier
- uon:52000
- Identifier
- ISSN:0028-3878
- Language
- eng
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